Database of Liver Modification Profile.dbLMP
Back Home
Total 2866 Records  First Page    1    2    3    4    5    6    7    8    9    10  Next Page   Last Page
IPI Number Protein Name SwissProte/Trembl/Ensembl Phosphorylation Site Scansite Stringency level Individual Motifs Motif Groups Protein Function Identified Phosphopeptides Charge
IPI00025039 Fibrillarin P22087 S126 Low Casein Kinase 2 Acidophilic serine/threonine kinase group Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. RVSIpSEGDDKIEYR 3
IPI00025084 Calpain small subunit 1 P04632 S88 No Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction THYpSNIEANESEEVR 2
IPI00025100 "2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor" P12694 S337 Low Clk2 Kinase Basophilic serine/threonine kinase group "The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)." IGHHpSpTSDDSSAYR 2
IPI00025100 "2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor" P12694 S339 Low Clk2 Kinase Basophilic serine/threonine kinase group "The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)." IGHHSpTpSDDSSAYRSVDEVNYWDK 3
IPI00025100 "2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor" P12694 S342 Low Casein Kinase 1 Acidophilic serine/threonine kinase group "The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)." IGHHSTSDDpSSAYRSVDEVNYWDK 3
IPI00025100 "2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor" P12694 S347 Low DNA PK DNA damage kinase group "The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)." IGHHpSTSDDSSAYRpSVDEVNYWDK 3
IPI00025100 "2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor" P12694 T338 No "The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)." IGHHpSpTSDDSSAYR 2
IPI00025156 Splice Isoform 1 of STIP1 homology and U box-containing protein 1 Q9UNE7 S19 Medium Cdk5 Kinase Proline-dependent serine/threonine kinase group "Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation" LGAGGGpSPEKSPSAQELK 2
IPI00025156 Splice Isoform 1 of STIP1 homology and U box-containing protein 1 Q9UNE7 S23 Low Cdk5 Kinase Proline-dependent serine/threonine kinase group "Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation" LGAGGGSPEKpSPSAQELK 2
IPI00025512 Heat-shock protein beta-1 P04792 S15 Low PKC mu Basophilic serine/threonine kinase group Involved in stress resistance and actin organization. GPpSWDPFR 2
IPI00025512 Heat-shock protein beta-1 P04792 S199 No Involved in stress resistance and actin organization. AQLGGPEAAKpSDETAAK 2
IPI00025512 Heat-shock protein beta-1 P04792 S82 Low PKC mu Basophilic serine/threonine kinase group Involved in stress resistance and actin organization. QLpSSGVSEIR 2
IPI00025512 Heat-shock protein beta-1 P04792 S98 Low Protein Kinase A Basophilic serine/threonine kinase group Involved in stress resistance and actin organization. WRVpSLDVNHFAPDELTVK 3
IPI00025707 Splice Isoform Long of Protein UBASH3A P57075 S477 Low 14-3-3 Mode 1 Phosphoserine/threonine binding group "Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface" ISpSVFASPALR 2
IPI00025746 Hypothetical protein LOC129138 Q6NXT1 S63 Low Cdc2 Kinase Proline-dependent serine/threonine kinase group N ASGGAQpSPLR 2
IPI00025804 High affinity immunoglobulin epsilon receptor gamma-subunit precursor P30273 S69 Low PDK1 Binding Kinase binding site group Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface SDGVYTGLpSTR 2
IPI00031670 Hypothetical protein LOC92689 Q6MZV4 S261 Medium Akt Kinase Basophilic serine/threonine kinase group N TVpSLSQM*LR 2
IPI00031698 Hypothetical protein MGC5509 Q9BVC5 S189 High GSK3 Kinase Acidophilic serine/threonine kinase group N KSPSGPVKpSPPLSPVGTTPVK 3
IPI00031812 Nuclease sensitive element-binding protein 1 P67809 S164 Low Casein Kinase 2 Acidophilic serine/threonine kinase group Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors NYQQNYQNpSESGEKNEGSESAPEGQAQQR 3
IPI00031812 Nuclease sensitive element-binding protein 1 P67809 S166 Low ATM Kinase DNA damage kinase group Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors NYQQNYQNSEpSGEKNEGSESAPEGQAQQR 3
IPI00031812 Nuclease sensitive element-binding protein 1 P67809 S173 Low Casein Kinase 2 Acidophilic serine/threonine kinase group Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors NYQQNYQNSESGEKNEGpSESAPEGQAQQR 3
IPI00032003 Emerin P50402 S60 High PDK1 Binding Kinase binding site group "Defects in EMD are a cause of X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) [MIM:310300]. X-EDMD is an X-linked disorder characterized by early contractures, muscle wasting and weakness and cardiomyopathy" LSPPSSSAASSYpSFSDLNSTR 2
IPI00032150 Splice Isoform 1 of Phosphatidate cytidylyltransferase 2 O95674 S21 High Casein Kinase 2 Acidophilic serine/threonine kinase group "Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin" VAHEPVAPPEDKEpSEpSEAKVDGETASDSESR 3
IPI00032150 Splice Isoform 1 of Phosphatidate cytidylyltransferase 2 O95674 S23 Low Casein Kinase 2 Acidophilic serine/threonine kinase group "Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin" VAHEPVAPPEDKEpSEpSEAKVDGETASDSESR 3
IPI00032150 Splice Isoform 1 of Phosphatidate cytidylyltransferase 2 O95674 S33 Low Casein Kinase 2 Acidophilic serine/threonine kinase group "Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin" VAHEPVAPPEDKESESEAKVDGETApSDSESR 3
IPI00032150 Splice Isoform 1 of Phosphatidate cytidylyltransferase 2 O95674 S37 Medium Casein Kinase 2 Acidophilic serine/threonine kinase group "Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin" VDGETASDSEpSRAESAPLPVSADDTPEVLNR 3
IPI00032150 Splice Isoform 1 of Phosphatidate cytidylyltransferase 2 O95674 T31 Medium Casein Kinase 2 Acidophilic serine/threonine kinase group "Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin" VAHEPVAPPEDKESESEAKVDGEpTASDSESR 3
IPI00032206 Splice Isoform 1 of PDZ and LIM domain protein 4 P50479 S112 Low Cdc2 Kinase Proline-dependent serine/threonine kinase group "Genetic variations in PDLIM4 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture." IHIDPEIQDGpSPTTSR 2
IPI00032230 Splice Isoform A of Band 4.1-like protein 3 Q9Y2J2 S420 Medium Protein Kinase A Basophilic serine/threonine kinase group Critical growth regulator in the pathogenesis of meningiomas RApSALIDRPAPYFER 3
IPI00032263 KIAA0999 protein Q59FY2 S626 Medium Protein Kinase A Basophilic serine/threonine kinase group Activated by phosphorylation on Thr-163 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. RFpSDGAASIQAFK 2
IPI00025839 Splice Isoform A of Hepatocyte nuclear factor 1-alpha P20823 S247 Low 14-3-3 Mode 1 Phosphoserine/threonine binding group Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. GVpSPSQAQGLGSNLVTEVR 2
IPI00026059 basic beta 1 syntrophin Q13884 S205 Medium Protein Kinase A Basophilic serine/threonine kinase group Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex KGpSPVSEIGWETPPPESPR 2
IPI00026059 basic beta 1 syntrophin Q13884 S219 Medium Cdc2 Kinase Proline-dependent serine/threonine kinase group Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex GSPVSEIGWETPPPEpSPR 2
IPI00026059 basic beta 1 syntrophin Q13884 S389 Low Cdk5 Kinase Proline-dependent serine/threonine kinase group Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex LVHSGPGKGpSPQAGVDLSFATR 3
IPI00026059 basic beta 1 syntrophin Q13884 S397 Low ATM Kinase DNA damage kinase group Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex LVHSGPGKGSPQAGVDLpSFATR 2
IPI00026059 basic beta 1 syntrophin Q13884 S87 Low Cdc2 Kinase Proline-dependent serine/threonine kinase group Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex GAGAGHPGAGGAQPPDpSPAGVR 2
IPI00026059 basic beta 1 syntrophin Q13884 T214 Medium Erk1 Kinase Proline-dependent serine/threonine kinase group Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex KGSPVSEIGWEpTPPPEpSPR 3
IPI00026202 60S ribosomal protein L18a Q02543 S71 Medium Cdk5 Kinase Proline-dependent serine/threonine kinase group N SSGEIVYCGQVFEKpSPLR 2
IPI00026230 Heterogeneous nuclear ribonucleoprotein H' P55795 S104 Medium Erk1 Kinase Proline-dependent serine/threonine kinase group "This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG)." HTGPNpSPDTANDGFVR 3
IPI00026230 Heterogeneous nuclear ribonucleoprotein H' P55795 T100 Low GSK3 Kinase Acidophilic serine/threonine kinase group "This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG)." HpTGPNSPDTANDGFVR 3
IPI00026230 Heterogeneous nuclear ribonucleoprotein H' P55795 T107 No "This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG)." HTGPNSPDpTANDGFVR 2
IPI00026260 Nucleoside diphosphate kinase B P22392 T94 No Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. VM*LGEpTNPADSKPGTIR 2
IPI00026320 Ubiquitin-protein ligase EDD1 O95071 S1549 Low DNA PK DNA damage kinase group "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation By similarity. May be involved in maturation and/or This protein may be involved in maturation and/or post-transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response. Plays an essential role in extraembryonic development" RIpSQSQPVR 2
IPI00026530 ERGIC-53 protein precursor P49257 S425 No "Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins" LVSGM*QHPGpSAGGVYETTQHFIDIK 3
IPI00026848 Alpha-2-macroglobulin receptor-associated protein precursor P30533 S247 No "Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis" RVSHQGYpSTEAEFEEPR 2
IPI00026848 Alpha-2-macroglobulin receptor-associated protein precursor P30533 T248 Low Casein Kinase 2 Acidophilic serine/threonine kinase group "Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis" RVSHQGYSpTEAEFEEPR 3
IPI00027035 XPA-binding protein 1 Q9HCN4 S338 High Casein Kinase 2 Acidophilic serine/threonine kinase group "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA" GTLDEEDEEADpSDTDDIDHR 2
IPI00027035 XPA-binding protein 1 Q9HCN4 T328 High PKC epsilon Basophilic serine/threonine kinase group "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA" GpTLDEEDEEADSDTDDIDHR 2
IPI00027248 Tumor suppressor candidate 2 O75896 S49 High PKC epsilon Basophilic serine/threonine kinase group "May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells" RGpSM*FYDEDGDLAHEFYEETIVTK 3
IPI00027258 Splice Isoform 2 of Synaptopodin Q8N3V7 S441 Low Protein Kinase A Basophilic serine/threonine kinase group "Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity" DRApSPAAAEEVVPEWASCLK 2
IPI00027258 Splice Isoform 2 of Synaptopodin Q8N3V7 S589 Low Cdk5 Kinase Proline-dependent serine/threonine kinase group "Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity" AApSPAKPSSLDLVPNLPK 2
IPI00027258 Splice Isoform 2 of Synaptopodin Q8N3V7 S804 Medium Cdk5 Kinase Proline-dependent serine/threonine kinase group "Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity" M*RpSPQPARPGSAAVPGAAFAPIPR 3
IPI00027430 Leukosialin precursor P16150 T341 High Protein Kinase A Basophilic serine/threonine kinase group One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 By similarity. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response RPpTLTTFFGR 2
IPI00027436 Tumor necrosis factor receptor superfamily member 16 precursor P08138 S313 No "Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells" LHSDSGISVDSQpSLHDQQPHTQTASGQALK 3
IPI00027563 zinc finger protein 382 Q96SR6 S533 Low PKC zeta Basophilic serine/threonine kinase group Functions as a sequence-specific transcriptional repressor QCGKFFSCKpSNLIVHQK 2
IPI00027781 Receptor-transporting protein 3 Q9BQQ7 S181 Low Akt Kinase Basophilic serine/threonine kinase group N VHpSIYK 2
IPI00028065 Cytoplasmic protein NCK1 P16333 S85 Medium 14-3-3 Mode 1 Phosphoserine/threonine binding group Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1 KPpSVPDSASPADDSFVDPGER 2
IPI00028065 Cytoplasmic protein NCK1 P16333 S89 Medium GSK3 Kinase Acidophilic serine/threonine kinase group Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1 RKPSVPDpSASPADDSFVDPGER 3
IPI00028065 Cytoplasmic protein NCK1 P16333 S91 Low Casein Kinase 2 Acidophilic serine/threonine kinase group Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1 RKPSVPDSApSPADDSFVDPGER 2
IPI00028359 Hypothetical protein DKFZp761F0123 Q7L8J4 S362 No N GLSDHVpSLDGQELGTR 2
IPI00028911 Dystroglycan precursor Q14118 S812 No Forms part of the dystrophin-associated protein complex (DAPC) which may link the cytoskeleton to the extracellular matrix. Alpha-dystroglycan functions as a laminin receptor. Binds to several types of arenaviruses. Is a target for the entry of Mycobacterium leprae into peripheral nerve Schwann cells KGVPIIFADELDDSKPPPpSSSM*PLILQEEK 3
IPI00028955 Ribosome biogenesis protein BOP1 Q14137 S126 High Casein Kinase 2 Acidophilic serine/threonine kinase group Required for maturation of the 25S and 5.8S ribosomal RNAs. Required for proper processing at four distinct sites located within the internal transcribed spacers ITS1 and ITS2 and the 3'-external spacer. May serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA IGDEYAEDpSpSDEEDIR 2
IPI00028955 Ribosome biogenesis protein BOP1 Q14137 S127 High Casein Kinase 2 Acidophilic serine/threonine kinase group Required for maturation of the 25S and 5.8S ribosomal RNAs. Required for proper processing at four distinct sites located within the internal transcribed spacers ITS1 and ITS2 and the 3'-external spacer. May serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA IGDEYAEDpSpSDEEDIR 2
IPI00029012 Eukaryotic translation initiation factor 3 subunit 10 Q14152 S881 Low Clk2 Kinase Basophilic serine/threonine kinase group Binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. May act as an adapter molecule between the translation initiation apparatus and the cytoskeleton structure in the cell RLGDpSSLSR 2
IPI00029048 Tubulin--tyrosine ligase-like protein 12 Q14166 S15 No N pSSPGQTPEEGAQALAEFAALHGPALR 2
IPI00029159 Splice Isoform 1 of Double-strand break repair protein MRE11A P49959 S688 High Casein Kinase 2 Acidophilic serine/threonine kinase group "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity." GVDFEpSSEDDDDDPFM*NTSSLR 2
IPI00029455 Multidrug resistance-associated protein 6 O95255 S278 Low PKC zeta Basophilic serine/threonine kinase group May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as Leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). KGGpSGM*KAPETEPFLR 3
IPI00029601 Src substrate cortactin Q14247 S406 High Erk1 Kinase Proline-dependent serine/threonine kinase group May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation AKpTQTPPVpSPAPQPTEER 3
IPI00029601 Src substrate cortactin Q14247 S418 Medium 14-3-3 Mode 1 Phosphoserine/threonine binding group May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation LPpSSPVYEDAASFK 2
IPI00029601 Src substrate cortactin Q14247 S419 Low Cdc2 Kinase Proline-dependent serine/threonine kinase group May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation LPSpSPVYEDAASFK 2
IPI00029601 Src substrate cortactin Q14247 T400 Medium 14-3-3 Mode 1 Phosphoserine/threonine binding group May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation AKpTQTPPVpSPAPQPTEER 3
IPI00029601 Src substrate cortactin Q14247 T402 Medium GSK3 Kinase Acidophilic serine/threonine kinase group May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation AKTQpTPPVpSPAPQPTEER 3
IPI00029730 Syntaxin-4 Q12846 S117 No Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane By similarity. May also play a role in docking of synaptic vesicles at presynaptic active zones. AIEPQKEEADENYNpSVNTR 2
IPI00029730 Syntaxin-4 Q12846 S208 No Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane By similarity. May also play a role in docking of synaptic vesicles at presynaptic active zones. HpSEIQQLER 2
IPI00029745 Nuclear factor 1 A-type Q12857 S280 High Calmodulin dependent Kinase 2 Basophilic serine/threonine kinase group Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. LKpSVEDEM*DpSPGEEPFYTGQGR 2
IPI00029745 Nuclear factor 1 A-type Q12857 S287 Medium Casein Kinase 2 Acidophilic serine/threonine kinase group Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. LKpSVEDEM*DpSPGEEPFYTGQGR 2
IPI00029745 Nuclear factor 1 A-type Q12857 S300 Low Cdc2 Kinase Proline-dependent serine/threonine kinase group Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. pSPGSGSQSSGWHEVEPGM*PSPTTLK 3
IPI00029745 Nuclear factor 1 A-type Q12857 S303 No Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. SPGpSGSQSSGWHEVEPGM*PSPTTLK 3
IPI00029997 6-phosphogluconolactonase O95336 S49 Low PKC mu Basophilic serine/threonine kinase group Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. FALGLSGGpSLVSM*LAR 2
IPI00030116 Splice Isoform 1 of Phosphoacetylglucosamine mutase O95394 S64 No Interconverts GlcNAc-6-P and GlcNAc-1-P. STIGVM*VTApSHNPEEDNGVK 2
IPI00030116 Splice Isoform 1 of Phosphoacetylglucosamine mutase O95394 T62 No Interconverts GlcNAc-6-P and GlcNAc-1-P. STIGVM*VpTASHNPEEDNGVK 2
IPI00030399 BCL2/adenovirus E1B 19-kDa protein-interacting protein 2 Q12982 S114 Medium Protein Kinase A Basophilic serine/threonine kinase group Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. KGpSITEYTAAEEK 2
IPI00030399 BCL2/adenovirus E1B 19-kDa protein-interacting protein 2 Q12982 T119 High Casein Kinase 2 Acidophilic serine/threonine kinase group Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. KGSITEYpTAAEEKEDGR 2
IPI00030911 Vesicle-associated membrane protein 8 Q9BV40 T48 Medium Calmodulin dependent Kinase 2 Basophilic serine/threonine kinase group "Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes" NKpTEDLEATSEHFK 2
IPI00030915 Ubiquitin carboxyl-terminal hydrolase 8 P40818 S716 Medium PKC epsilon Basophilic serine/threonine kinase group Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Involved in cell proliferation. Probably regulates the stability of STAM2 and RASGRF1. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. pSYSSPDITQAIQEEEKR 2
IPI00030915 Ubiquitin carboxyl-terminal hydrolase 8 P40818 S718 High 14-3-3 Mode 1 Phosphoserine/threonine binding group Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Involved in cell proliferation. Probably regulates the stability of STAM2 and RASGRF1. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. SYpSSPDITQAIQEEEKR 2
IPI00030917 Growth factor receptor-bound protein 14 Q14449 S370 No Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain pSISENSLVAM*DFSGQK 2
IPI00030917 Growth factor receptor-bound protein 14 Q14449 S372 Medium 14-3-3 Mode 1 Phosphoserine/threonine binding group Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain SIpSENSLVAM*DFSGQK 2
IPI00030968 Hypothetical protein C9orf142 Q9BUH6 S148 High Cdk5 Kinase Proline-dependent serine/threonine kinase group N LAAAEETAVpSPR 2
IPI00031008 Splice Isoform 1 of Tenascin precursor P24821 T1902 No "Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6." FTTDLDSPRDLTATEVQSEpTALLpTWRPPR 3
IPI00031008 Splice Isoform 1 of Tenascin precursor P24821 T1906 No "Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6." FTTDLDSPRDLTATEVQSEpTALLpTWRPPR 3
IPI00031091 EF-hand domain-containing protein 1 Q9BUP0 S22 No N REEAEEpSGPQLAPLGAPAPEPKPEPEPPAR 3
IPI00031347 NAD kinase O95544 S64 Medium 14-3-3 Mode 1 Phosphoserine/threonine binding group N TRpSLHGPCPVTTFGPK 3
IPI00031410 FKBP12-rapamycin complex-associated protein P42345 S1261 No "Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization" LHVpSTINLQK 2
IPI00031420 UDP-glucose 6-dehydrogenase O60701 S476 No "Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate." IPYAPpSGEIPK 2
IPI00031499 TMEM85 protein Q9BUI5 S36 Low Akt Kinase Basophilic serine/threonine kinase group N SDRGpSGQGDSLYPVGYLDK 2
IPI00031523 Heat shock protein 86 Q14568 S263 High Casein Kinase 2 Acidophilic serine/threonine kinase group Molecular chaperone ESKDKPEIEDVGpSDEEEEK 2
IPI00031556 Splicing factor U2AF 65 kDa subunit P26368 S79 High Cdc2 Kinase Proline-dependent serine/threonine kinase group "Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene." GAKEEHGGLIRpSPR 2
IPI00031563 Hypothetical protein DDA1 Q9BW61 S33 High Protein Kinase A Basophilic serine/threonine kinase group May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins RPpSVYLPTR 2
IPI00031622 Coiled-coil-helix-coiled-coil-helix domain-containing protein 6 Q9BRQ6 S13 High Protein Kinase A Basophilic serine/threonine kinase group N RVpSFGVDEEER 2